Navigating Mental Health During Motherhood: Medication, Misconceptions, and Compassionate Care

Omaha Mom Talks host, Jessie Gutierrez, sits down with Anne Hofer, a certified psychiatric nurse practitioner and founder of Her Story and Our Story clinics in Omaha, to unpack a deeply important topic: maternal mental health. Their conversation sheds light on the complexities of perinatal and postpartum mental health, the stigma surrounding medication, and the critical need for informed, compassionate care.

Anne Hofer brings both professional expertise and personal experience to the table. After struggling with postpartum mood issues herself and receiving misleading information about medication, she was driven to specialize in reproductive psychiatry. Today, her clinics provide evidence-based mental health services to women across the reproductive spectrum and extend support to families through Our Story.

Over the past 25 years, awareness around maternal mental health has grown significantly. While early research focused primarily on the effects of medications on fetal development, recent studies have shifted the focus to the risks of untreated mental illness in pregnancy. Anxiety, depression, and trauma during pregnancy can elevate maternal cortisol levels, which in turn may increase a baby’s baseline stress levels and risk of complications like preeclampsia and preterm labor. The current consensus: treating maternal mental health is essential for the well-being of both mother and child.

Jessie and Anne discuss the persistent myths surrounding antidepressant use in pregnancy and breastfeeding. Hofer emphasizes that SSRIs, like sertraline (Zoloft), have been thoroughly studied and are generally safe. In fact, there’s more evidence supporting their safety than for some commonly used antibiotics in pregnancy. Despite this, many providers, especially in rural areas or general practice settings, still perpetuate outdated beliefs. Hofer encourages women to seek out specialists in reproductive psychiatry if they feel their needs aren’t being met.

Medication is not a one-size-fits-all solution. Hofer explains the importance of finding the lowest effective dose—not the lowest possible dose—and reassures patients that being on medication doesn’t mean a lifetime commitment. Standard guidelines suggest maintaining treatment for at least a year before reassessing, but decisions are made collaboratively with each patient. Genetic testing is available for those interested, though it has its limitations and isn’t always more effective than trial and error.

Jessie and Anne also discuss the emotional barriers that keep women from seeking medication—fear of weakness, stigma, and preference for “natural” alternatives like supplements. Hofer respectfully challenges these beliefs, pointing out that many supplements lack the clinical research and regulation that psychiatric medications have. Comparing mental health treatment to diabetes management, she reinforces the idea that mental illness isn’t a personal failing—it’s a medical condition that deserves care.

One of the most impactful takeaways from the episode is the power of validation and nonjudgmental support. Whether it’s a partner, friend, or provider, simply acknowledging a mother’s struggles can open the door to healing. Hofer highlights the joy she feels when former patients return during subsequent pregnancies feeling more empowered, present, and joyful—a testament to the difference that proper support can make.
For those looking to connect with Anne Hofer’s team, more information is available at herstoryomaha.com and ourstoryomaha.com. And as always, Omaha Mom Talks encourages listeners to reach out, share their stories, and know they’re not alone.

This blog post is based on a transcript from the Omaha Mom Talks podcast episode released on July 7th 2025.

Omaha Mom Talks is all about creating connection for moms in Omaha, Nebraska. Join your host, Jessie Gutierrez, a mental health therapist and mom of two, to explore the joys and struggles of motherhood, the importance of mental health, and the best Omaha has to offer. Whether you’re a new mom or a seasoned pro, each episode brings you expert advice, community stories, and local gems to support you on your motherhood journey.

Edited by Grace Dunbar